Apply a few drops to clean, dry skin in the evening, smoothing evenly across the face and neck while avoiding the eye area. If you are new to retinoids, start by using 2–3 times per week and gradually increase frequency as your skin adjusts. Always follow with a nourishing moisturiser to minimise dryness or flaking. In the daytime, apply a high-factor broad-spectrum sunscreen, as retinoids increase skin sensitivity to UV radiation